GC-MS Analysis and Thrombolytic Property of Methanolic Leaf Extracts of Terminalia pallida Brandis against Carrageenan Instigated Tail Thrombosis Model in Mice

Pharmacognosy Research,2022,14,1,53-60.DOI:10.5530/pres.14.1.9Published:January 2021Type:Research ArticleAuthors:Sarvan Kumar Guguloth, Narender Malothu, and Prasanth DSNBK Author(s) affiliations:Sarvan Guguloth1,2, Malothu1,*, DSNBK1 1Department of Pharmaceutical Chemistry, KL College Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, INDIA. 2Department Pharmacology, Vijaya Munaganoor, Hayathnagar, Ranga Reddy, Telangana, Abstract:Background: Several plants Terminalia species are being reported as medicinally useful. pallida Brandis is one the Combretaceae family, which constitutes several pharmacologically active substances. Present work explored leaf extract’s thrombolytic property, could serve superior choice for currently using drugs. Objectives: The present study primarily focused on investigating phyto-constituents such phenolic flavonoid compounds in methanolic extract followed by GC-MS analysis determining vitro thrombin inhibition vivo thrombolysis activity. Materials Methods: Swiss albino mice (total = 36) were randomly distributed into six groups (n=6). Thrombosis was instigated injecting 40 μL 1% carrageenan (Type-I) via subplantar region right hind paw each mouse. plant screened its inhibitory potency. In animal studies, size blood clots mouse tails recorded administering extracts at 100, 200 300 mg/kg body weight every 24, 48 72 hr, respectively. Results: A dose showed significant activity 48, hr (p< 0.001) a concentration-dependent manner when correlated with control group. reduction length 0.01) observed hr. acute oral toxicity study, administration no mortality behavioral changes up to 2000 dose. occurrence about 16 eluted compounds; among these, few have been useful, accounts therapeutic importance plant. Conclusion: conclusion, T. leaves 200, model Keywords:Carrageenan, Heparin, Quercetin., Terminallia Brandis, ThrombosisView:PDF (4.38 MB) Full Text